Potassium tert-butoxide → 2-methyl-2H-pyran-3,5(4H,6H)-dione

HRID 1837097Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1837097
CC(C)([O-])C.[K+].[CH3:7][CH:8]([O:12][CH2:13][C:14]([O:16]C)=O)[C:9](=[O:11])[CH3:10]>C(O)(C)(C)C.CCOCC>[CH3:7][CH:8]1[C:9](=[O:11])[CH2:10][C:14](=[O:16])[CH2:13][O:12]1

Komponenten

5

Edukt 2

HCID 23665647Potassium tert-butoxideHCID 71360827Methyl (1-methyl-2-oxopropoxy)acetate

Produkt 1

HCID 234974742-methyl-2H-pyran-3,5(4H,6H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

Potassium tert-butoxide in tert-butanol (1 M, 203 mL) and the product from Example 44B (15.5 g, 97 mmol) in ether (55 mL) were processed as described in Example 43C. The residue was purified on silica gel eluting with ethyl acetate:formic acid:water:hexane (200:1:1:200) provided the title compound. 1H NMR (CDCl3) δ 1.48 (d, 3H), 3.43 (d, 1H), 3.92 (d, 1H), 3.97 (q, 1H), 4.04 (d, 1H), 4.44 (d, 1H).

Aufarbeitung

  1. customThe residue was purified on silica gel eluting with ethyl acetate:formic acid:water:hexane (200:1:1:200)

Quellen und Nachweise

ORD-Eintrag
ord-40aaaa9b0f7e4af2afa1164456245a56
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06780872B2

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