Reaktionsgleichung
[Na].[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([O:10][CH3:11])=[CH:5][C:4]=1[NH:12][C:13]1[C:22]2[C:17](=[CH:18][C:19](F)=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][C:14]=1[C:26]#[N:27].[CH3:28][O:29][CH2:30][CH2:31][OH:32]>>[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([O:10][CH3:11])=[CH:5][C:4]=1[NH:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:32][CH2:31][CH2:30][O:29][CH3:28])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][C:14]=1[C:26]#[N:27]Komponenten
Reaktionsbedingungen
- Temperatur
- 125 °C
Versuchsvorschrift
A mixture of sodium (118 mg, 5.11 mmol) and 2-methoxyethanol (5 mL) is heated at 120-130° C. for 3 hours. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile (500 mg, 1.28 mmol) is added and the reaction mixture is heated at 120-125° C. for 1 hour. The temperature of the reaction mixture is increased to 140-150° C. and this temperature is maintained for 2.5 hours. The reaction mixture is cooled to room temperature and diluted with ice cold aqueous sodium bicarbonate. The solid is collected by filtration washing with water and hexane. Purification by flash column chromatography, eluting with 2% methanol in dichloromethane provides 550 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[2-methoxyethoxy]-3-quinolinecarbonitrile, mp 210-212° C.
Aufarbeitung
- temperaturethe reaction mixture is heated at 120-125° C. for 1 hour
- temperatureThe temperature of the reaction mixture is increased to 140-150° C.
- temperaturethis temperature is maintained for 2.5 hours
- temperatureThe reaction mixture is cooled to room temperature
- additiondiluted with ice cold aqueous sodium bicarbonate
- filtrationThe solid is collected by filtration
- washwashing with water and hexane
- customPurification by flash column chromatography
- washeluting with 2% methanol in dichloromethane
Quellen und Nachweise
- ORD-Eintrag
- ord-af770a3ee36f4aa78aca38859b1212ac
- Quelldatensatz
- uspto-grants-2004_08
- Patentnummer
- US06780996B2
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