Trimethyl orthoformate → HCID 22678608, Verbindung

HRID 1837710Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1837710
[Br:1][C:2]1[CH:3]=[C:4](C=O)[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH:12]([O:17][CH3:18])([O:15][CH3:16])OC.O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3]>ClCCl>[CH3:18][O:17][CH:12]([O:15][CH3:16])[C:4]1[C:5]([O:8][CH3:9])=[N:6][CH:7]=[C:2]([Br:1])[CH:3]=1

Komponenten

5

Edukt 3

HCID 9005Trimethyl orthoformateHCID 15164035-Bromo-2-methoxypyridine-3-carbaldehydeHCID 71586775Bentonite

Produkt 1

HCID 22678608HCID 22678608, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2.58 g of 5-bromo-2-methoxy-3-pyridinecarboxaldehyde was dissolved in 30 ml of dichloromethane, a mixture of 9 ml of trimethyl orthoformate and montmorillonite K-10 (3 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. After filtering the reaction solution, the filtrate was evaporated. To the residue was added ethyl acetate, followed by filtering through alumina. The filtrate was evaporated, to give 3.09 g of the title compound as a yellow oil.

Aufarbeitung

  1. additionwas added
  2. filtrationAfter filtering the reaction solution
  3. customthe filtrate was evaporated
  4. additionTo the residue was added ethyl acetate
  5. filtrationby filtering through alumina
  6. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c6c9ebe904244d8a947ff498a75c7d9b
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06784192B2

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