Oxalyl chloride → 4-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride

HRID 1843056Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1843056
[F:1][CH:2]([F:19])[C:3]1[C:8]([C:9](O)=[O:10])=[CH:7][N:6]=[C:5]([C:12]([F:18])([F:17])[C:13]([F:16])([F:15])[F:14])[N:4]=1.C(Cl)(=O)C([Cl:23])=O>ClCCl.CN(C)C=O>[F:1][CH:2]([F:19])[C:3]1[C:8]([C:9]([Cl:23])=[O:10])=[CH:7][N:6]=[C:5]([C:12]([F:18])([F:17])[C:13]([F:16])([F:15])[F:14])[N:4]=1

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 866600764-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid

Produkt 1

HCID 866600754-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

In 10 ml of dichloromethane, 467 mg of 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid are admixed with two drops of N,N-dimethylformamide and cooled to 0° C. Following the dropwise addition of 167 μl of oxalyl chloride, the reaction mixture is stirred at room temperature for three hours and then concentrated by evaporation. This gives the crude product 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride.

Aufarbeitung

  1. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-8dd05b45fa9347e3abbf331a6b713599
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946234B2

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