HCID 178526612, Verbindung → HCID 178507541, Verbindung

HRID 1843602

Reaktionsgleichung

Reaktionsgleichung von HRID 1843602
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[C:14]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)=[CH:13][NH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[N:18]1[CH:17]=[CH:16][C:15]([C:14]2[C:10]([C:6]3[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=3)=[N:11][NH:12][CH:13]=2)=[CH:20][CH:19]=1

Komponenten

4

Edukt 1

HCID 178526612HCID 178526612, Verbindung

Produkt 1

HCID 178507541HCID 178507541, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.27 g (4.77 mmol) of 4-[3-(3-nitro-phenyl)-1H-pyrazol-4-yl]-pyridine was suspended in methanol (200 mL). Pd/C 10% (250 mg) was added and the mixture was agitated under hydrogen pressure (50 psi) in a Parr apparatus at room temperature for 4 hours. The catalyst was then filtered on a Celite pad and washed with methanol. The filtrate was concentrated to dryness to obtain 1.1 g (98% yield) of 3-(4-pyridin-4-yl-1H-pyrazol-3-yl)-phenylamine as an off-white solid.

Aufarbeitung

  1. filtrationThe catalyst was then filtered on a Celite pad
  2. washwashed with methanol
  3. concentrationThe filtrate was concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-0e641ff6cfea4fcabfb72ce34f0738fc
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946250B2

Verknüpfte Notizen

Wird geladen…