4-Methylpyridine → 1-(3-Dibenzylamino-2,6-difluoro-phenyl)-2-pyridin-4-yl-ethanone

HRID 1843631

Reaktionsgleichung

Reaktionsgleichung von HRID 1843631
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.C[Si](C)(C)[N-][Si](C)(C)C.[Na+].C([O:25][C:26](=O)[C:27]1[C:32]([F:33])=[CH:31][CH:30]=[C:29]([N:34]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:28]=1[F:49])C1C=CC=CC=1.[Cl-].[NH4+]>O1CCCC1>[CH2:42]([N:34]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:29]1[C:28]([F:49])=[C:27]([C:26](=[O:25])[CH2:1][C:2]2[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=2)[C:32]([F:33])=[CH:31][CH:30]=1)[C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=1

Komponenten

6

Edukt 4

HCID 79634-Methylpyridine2×HCID 25517Ammonium ChlorideHCID 2724254Sodium bis(trimethylsilyl)amideHCID 584771183-Dibenzylamino-2,6-difluoro-benzoic acid benzyl ester

Produkt 1

HCID 584771201-(3-Dibenzylamino-2,6-difluoro-phenyl)-2-pyridin-4-yl-ethanoneAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

To 4-methyl-pyridine (806 μL, 8.33 mmol) in anhydrous tetrahydrofuran (35 mL) was added at 0° C. sodium hexamethyldisilazide 1 M in tetrahydrofuran (16.66 mL, 16.66 mmol) and the reaction was stirred for 20 minutes. 3-Dibenzylamino-2,6-difluoro-benzoic acid benzyl ester (3.691 g, 8.33 mmol) was dissolved in tetrahydrofuran (5 mL) and added dropwise to the solution with 4-methyl-pyridine, the reaction was stirred at 0° C. for one hour. The reaction was poured into saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtrate and concentrated under reduced pressure. The crude was purified by silica gel column chromatography eluting with ethyl acetate 30% in hexane to give the title compound (1.775 g, 50%).

Aufarbeitung

  1. stirringthe reaction was stirred at 0° C. for one hour
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate, filtrate
  5. concentrationconcentrated under reduced pressure
  6. customThe crude was purified by silica gel column chromatography
  7. washeluting with ethyl acetate 30% in hexane

Quellen und Nachweise

ORD-Eintrag
ord-2c1c7d9b5611406abc6880f3ce0b7553
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946250B2

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