Trifluoroacetic acid → HCID 178482071, Verbindung

HRID 1843654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1843654
COC1C=CC(C[N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH3:20])[CH:14]=3)[C:10]([C:21]3[CH:22]=[C:23]([NH:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=4)=[O:29])[CH:24]=[CH:25][CH:26]=3)=[N:9]2)=CC=1.FC(F)(F)C(O)=O>C(OCC)C>[CH3:20][NH:19][C:15]1[CH:14]=[C:13]([C:11]2[C:10]([C:21]3[CH:22]=[C:23]([NH:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:38])[F:39])=[CH:33][CH:32]=4)=[O:29])[CH:24]=[CH:25][CH:26]=3)=[N:9][NH:8][CH:12]=2)[CH:18]=[CH:17][N:16]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 671843231-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea

Produkt 1

HCID 178482071HCID 178482071, VerbindungAusbeute 63,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

200 mg (0.35 mmol) of 1-(3-{1-(4-methoxybenzyl)-4-[2-(methylamino)pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-3-[4-(trifluoromethyl)phenyl]urea were dissolved with 10 ml of trifluoroacetic acid and the solution was stirred at 70° C. for 6 hours. The solvent was then evaporated and the residue taken up with dichloromethane and washed with aqueous sodium hydrogenocarbonate. The organic layer was dried over sodium sulphate and evaporated again, affording, after trituration with diethylether, 100 mg (63%) of the title compound.

Aufarbeitung

  1. customThe solvent was then evaporated
  2. washwashed with aqueous sodium hydrogenocarbonate
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. customevaporated again
  5. customaffording

Quellen und Nachweise

ORD-Eintrag
ord-dceb608013c64d3a89623b4ddfe6a695
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946250B2

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