Oxalyl chloride → 4-Methoxybenzoyl isocyanate
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1.C(Cl)(=O)[C:13](Cl)=[O:14]>ClCCl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([N:9]=[C:13]=[O:14])=[O:8])=[CH:5][CH:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 4-methoxybenzamide (2.6 mmol) in dichloromethane (10 mL) was added oxalyl chloride 98% (6.61 mmol) dropwise. The mixture was heated to reflux for 20 h. Reaction completion monitored by TLC. The solvent was removed in vacuo (40° C., 760 mmHg) to obtain title compound D11, which was immediately used without purification.
Aufarbeitung
- temperatureThe mixture was heated
- temperatureto reflux for 20 h
- customReaction completion
- customThe solvent was removed in vacuo (40° C., 760 mmHg)
Quellen und Nachweise
- ORD-Eintrag
- ord-60b3d5dd1f9f44979c3b59744d782027
- Quelldatensatz
- uspto-grants-2015_02
- Patentnummer
- US08946282B2
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