Sulfuryl chloride → Ethyl 2-chloro-3-cyclopropyl-3-oxopropanoate

HRID 1844138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1844138
S(Cl)([Cl:4])(=O)=O.[CH:6]1([C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:8][CH2:7]1>ClCCl>[Cl:4][CH:10]([C:9]([CH:6]1[CH2:8][CH2:7]1)=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Komponenten

4

Edukt 2

HCID 24648Sulfuryl chlorideHCID 262979Ethyl 3-cyclopropyl-3-oxopropanoate

Produkt 1

HCID 54244501Ethyl 2-chloro-3-cyclopropyl-3-oxopropanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3.1 ml of sulphuryl chloride (38.2 mmol, 1.05 equivalents) were initially charged in 21 ml of dichloromethane, and 5.68 g of ethyl 3-cyclopropyl-3-oxopropanoate (36.4 mmol) were added dropwise on a water bath. The reaction mixture was stirred at RT for 2 h and then washed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over magnesium sulphate and concentrated. The crude product (6.8 g) was used without further purification for the next reaction.

Aufarbeitung

  1. washwashed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution
  2. dry with materialdried over magnesium sulphate
  3. concentrationconcentrated
  4. customThe crude product (6.8 g) was used without further purification for the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-6f11f49505f84107b5fc46c4b65c303e
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946215B2

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