Hydroxylamine → Ethyl 6-chloro-2-fluoro-3-((hydroxyimino)methyl)benzoate

HRID 1846107Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846107
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[C:7]([CH:12]=O)[C:6]=1[F:14])[CH3:2].[NH2:16][OH:17]>CO>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[C:7]([CH:12]=[N:16][OH:17])[C:6]=1[F:14])[CH3:2]

Komponenten

4

Edukt 2

HCID 787HydroxylamineHCID 58483266Ethyl 6-chloro-2-fluoro-3-formylbenzoate

Produkt 1

HCID 76800184Ethyl 6-chloro-2-fluoro-3-((hydroxyimino)methyl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

A mixture of 6-chloro-2-fluoro-3-formyl-benzoic acid ethyl ester (4.04 g; 17.52 mmol), hydroxylamine (50% aq. solution, 4.29 mL; 70 mmol) in MeOH (60 mL) was stirred at 55° C. for 1.5 h. The mixture was concentrated i. vac., diluted with EtOAc, washed with brine, dried over Na2SO4 and concentrated i.vac. to furnish the subtitle compound.

Aufarbeitung

  1. concentrationThe mixture was concentrated i
  2. addition, diluted with EtOAc
  3. washwashed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated i.vac

Quellen und Nachweise

ORD-Eintrag
ord-dd0871d3f04b4e3790673be115def190
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08951999B2

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