Water → 6-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

HRID 1846418Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846418
[OH:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:19][C:20]1[CH:25]=[C:24](Cl)[N:23]=[CH:22][N:21]=1.O>CN(C=O)C>[Cl:19][C:20]1[N:21]=[CH:22][N:23]=[C:24]([O:1][C:2]2[CH:11]=[C:10]([CH3:12])[C:5]3[NH:6][C:7](=[O:9])[O:8][C:4]=3[CH:3]=2)[CH:25]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669780936-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one

Produkt 1

HCID 866638916-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

0.10 g (0.60 mmol) 6-hydroxy-4-methyl-3H-benzoxazol-2-one in 1.5 mL DMF were combined with 0.10 g (0.70 mmol) potassium carbonate and stirred for 15 min at RT. Then 0.10 g (0.60 mmol) 4,6-dichloropyrimidine were added to the reaction mixture and stirred overnight at RT. Then water was added and the precipitate formed was suction filtered, washed and dried i. vac.

Aufarbeitung

  1. stirringstirred overnight at RT
  2. customthe precipitate formed
  3. filtrationfiltered
  4. washwashed
  5. customdried i

Quellen und Nachweise

ORD-Eintrag
ord-07131b398064435881a0d3a6fe1e5e0c
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

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