Pyridinium chloride → 2-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

HRID 1846515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846515
C[O:2][C:3]1[CH:4]=[C:5]([C:13]([F:16])([F:15])[F:14])[C:6]2[N:10]=[C:9]([CH3:11])[NH:8][C:7]=2[CH:12]=1.Cl.N1C=CC=CC=1>CN(C=O)C>[CH3:11][C:9]1[NH:8][C:7]2[CH:12]=[C:3]([OH:2])[CH:4]=[C:5]([C:13]([F:16])([F:14])[F:15])[C:6]=2[N:10]=1

Komponenten

4

Edukt 2

HCID 10176127Pyridinium chlorideHCID 669782136-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole

Produkt 1

HCID 669782592-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A well stirred mixture of 450 mg (1.95 mmol) 6-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole and 2.50 g (21.6 mmol) pyridine hydrochloride was heated for 15 min to 200° C. After cooling to RT the reaction mixture was combined with 3.0 mL DMF and purified by preparative HPLC. The fractions containing product were combined and evaporated down i.vac.

Aufarbeitung

  1. temperaturewas heated for 15 min to 200° C
  2. custompurified by preparative HPLC
  3. additionThe fractions containing product
  4. customevaporated down i.vac

Quellen und Nachweise

ORD-Eintrag
ord-68c0fe24adfa46c5894f204c1205570c
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

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