2,3-Difluoro-4-nitroanisole → 2,3-Difluoro-4-nitrophenol
Reaktionsgleichung
[F:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[O:12]C>Br.C(O)(=O)C>[F:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[OH:12]Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 2,3-difluoro-4-nitroanisole (10 g) in 48% HBr (60 mL) and 30% HBr in acetic acid (30 mL) was stirred at 120° C. overnight. The mixture was cooled to room temperature and extracted with ethyl acetate (3×200 mL) and the combined extracts were washed with brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the product.
Aufarbeitung
- extractionextracted with ethyl acetate (3×200 mL)
- washthe combined extracts were washed with brine
- dry with materialdried over Na2SO4
- filtrationFiltration and evaporation of the solvent
- customgave the product
Quellen und Nachweise
- ORD-Eintrag
- ord-02bf10277e064911b4f9a19f8b5e7696
- Quelldatensatz
- uspto-grants-2015_02
- Patentnummer
- US08952157B2
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