Pyridine → 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide

HRID 18509

Reaktionsgleichung

Reaktionsgleichung von HRID 18509
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.N1C=CC=CC=1.[Br:15][CH2:16][C:17](Br)=[O:18]>C1(C)C=CC=CC=1>[Br:15][CH2:16][C:17]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)=[O:18]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 61147Bromoacetyl bromideHCID 661742-Amino-5-chloropyridine

Produkt 1

HCID 34211102-Bromo-N-(5-chloro-2-pyridinyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.

Aufarbeitung

  1. additionwere added dropwise under ice cooling
  2. customAfter 2 h the precipitate was isolated by filtration
  3. customrecrystallized from toluene
  4. customto yield a white solid

Quellen und Nachweise

ORD-Eintrag
ord-31ec5a5ff49240e090abf794e19ea941
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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