Hydrochloric Acid → (3R)-ethyl 2-amino-3-ethyl-5-methylnon-8-enoate hydrochloride

HRID 1852199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1852199
C1(C(=[N:14][CH:15]([C@H:21]([CH2:29][CH3:30])[CH2:22][CH:23]([CH3:28])[CH2:24][CH2:25][CH:26]=[CH2:27])[C:16]([O:18][CH2:19][CH3:20])=[O:17])C2C=CC=CC=2)C=CC=CC=1.[ClH:31]>C(OCC)C>[ClH:31].[NH2:14][CH:15]([C@H:21]([CH2:29][CH3:30])[CH2:22][CH:23]([CH3:28])[CH2:24][CH2:25][CH:26]=[CH2:27])[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86683257(3R)-ethyl 2-(diphenylmethyleneamino)-3-ethyl-5-methylnon-8-enoate

Produkt 1

HCID 86683258(3R)-ethyl 2-amino-3-ethyl-5-methylnon-8-enoate hydrochlorideAusbeute 62,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of (3R)-ethyl 2-(diphenylmethyleneamino)-3-ethyl-5-methylnon-8-enoate (7 g, 17.26 mmole) in diethyl ether (20 mL) was added aqueous 1.5 N HCl solutions (100 mL) and the reaction mass was stirred at room temperature for overnight. The reaction mass was washed with diethyl ether (100 mL). The aqueous solution was basified using saturated sodium bicarbonate solution and extracted with ethyl acetate (100 mL×3). The combined organic layers were dried over anhydrous Na2SO4 and evaporated under reduced pressure to get crude compound (2.6 g, 62.4%). The crude compound was taken to the next step without further purification. MS: MS m/z 242.4 (M++1).

Aufarbeitung

  1. washThe reaction mass was washed with diethyl ether (100 mL)
  2. extractionextracted with ethyl acetate (100 mL×3)
  3. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
  4. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b59c8faa10724415b3442d3f2d009862
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957203B2

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