Water → 4-Methyl-1-nitro-2-[2-(2-nitrophenoxy)ethoxy]benzene

HRID 1852365Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1852365
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-:13])=[O:12].[CH3:14][C:15]1[CH:16]=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[C:19]([OH:21])[CH:20]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH3:14][C:15]1[CH:16]=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[C:19]([O:21][CH2:2][CH2:3][O:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N+:11]([O-:13])=[O:12])[CH:20]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 127886-Nitro-m-cresolHCID 43624871-(2-chloroethoxy)-2-nitrobenzene

Produkt 1

HCID 27630554-Methyl-1-nitro-2-[2-(2-nitrophenoxy)ethoxy]benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

1-(2-Chloro-ethoxy)-2-nitro-benzene (116 g) and 5-methyl-2-nitro-phenol (88 g) were dissolved in 500 ml DMF and was stirred for 4 h at 90-110° C. after careful addition of 160 g potassium carbonate. The reaction mixture was poured in a mixture of crushed ice and water (8 l) which was vigorously stirred. The residue was filtered off, washed several times with water and dried. The crude product was suspended in methanol and the pale yellow residue was again filtered off, washed with methanol and dried. Yield: 150-165 g.

Aufarbeitung

  1. stirringwas vigorously stirred
  2. filtrationThe residue was filtered off
  3. washwashed several times with water
  4. customdried
  5. filtrationthe pale yellow residue was again filtered off
  6. washwashed with methanol
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-22c6d06fd49b4326b2ec6360d3ecb503
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962338B2

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