Nitrogen → 6-Oxospiro[2.5]octane-5-carbonitrile

HRID 1852473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1852473
[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:7][CH2:6]2)[CH:4]=[C:3]1[C:10]#[N:11].N#N>CO.[Pd]>[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:6][CH2:7]2)[CH2:4][CH:3]1[C:10]#[N:11]

Komponenten

5

Edukt 2

HCID 947NitrogenHCID 867310096-Oxospiro[2.5]oct-4-ene-5-carbonitrile

Produkt 1

HCID 867310106-Oxospiro[2.5]octane-5-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

6-Oxospiro[2.5]oct-4-ene-5-carbonitrile (0.16 g, 1.1 mmol) was dissolved in MeOH (11 mL) and combined with 10% palladium on activated carbon (0.12 g, 0.11 mmol). The resulting mixture was subjected to alternating vacuum and H2 gas (4×). The mixture was then stirred under an atmosphere of H2 (50 psi) for 16 hours. The mixture was then subjected to alternating vacuum and N2 gas (4×). The mixture was filtered through celite and rinsed with MeOH. The filtrate was concentrated in vacuo to afford the title compound. The material was used without further purification.

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. washrinsed with MeOH
  3. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0c79da19d7264276beaac0fcf37660f1
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962608B2

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