Potassium Carbonate → HCID 59633880, Verbindung

HRID 1852585Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1852585
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][C:4]=1F)#[N:2].[C:23]([O-])([O-])=[O:24].[K+].[K+]>CO.O>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][C:4]=1[O:24][CH3:23])#[N:2]

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 59633877HCID 59633877, Verbindung

Produkt 1

HCID 59633880HCID 59633880, VerbindungAusbeute 102 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

A solution of 95 mg (0.32 mmol) of compound 9m was combined with 120 mg (0.87 mmol) of K2CO3 in 8 mL of MeOH and heated at 75° C. for 5 h. The mixture was cooled, diluted with water, and extracted with CH2Cl2. The organic solution was concentrated to give 100 mg (100%) of 9n as a white solid.

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. extractionextracted with CH2Cl2
  3. concentrationThe organic solution was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-db22ec1412404d8da633b9aa9d3a11d5
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962607B2

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