Reaktionsgleichung
[CH3:1][O:2][C:3]([C:5]1[C:13]2[N:12]=[C:11]([C:14](Cl)(Cl)Cl)[NH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][C:26]2=[O:31])=[CH:21][CH:20]=1.C([O-])(O)=[O:33].[Na+].O>C1COCC1.C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[C:13]2[N:12]=[C:11]([C:14](=[O:33])[NH:18][C:19]3[CH:20]=[CH:21][C:22]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][C:26]4=[O:31])=[CH:23][CH:24]=3)[NH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4]Komponenten
7
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 69.4 mg (0.236 mmol) methyl-2-trichloromethyl-1H-benzoimidazole-4-carboxylate in 2 mL THF were slowly added to a mixture containing 50 mg (0.26 mmol) 4-(4-amino-phenyl)-morpholin-3-one, 220 mg (2.62 mmol) NaHCO3, 8 mL THF and 3 mL H2O. The mixture was stirred vigorously for 3 h at room temperature, diluted with 50 mL CH2Cl2 and washed with 30 mL of a saturated NaHCO3-solution. The aqueous solution was extracted with 50 mL CH2Cl2 and the combined organic layers were dried over MgSO4 and concentrated under reduced pressure to give a brown solid, which was pure enough for the following reactions.
Aufarbeitung
- washwashed with 30 mL of a saturated NaHCO3-solution
- extractionThe aqueous solution was extracted with 50 mL CH2Cl2
- dry with materialthe combined organic layers were dried over MgSO4
- concentrationconcentrated under reduced pressure
- customto give a brown solid, which
Quellen und Nachweise
- ORD-Eintrag
- ord-11753aeeb2984b2f8a99a7765cca0429
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07741341B2
Verknüpfte Notizen
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