Toluene → Benzimidazole, 2-trichloromethyl-

HRID 18532

Reaktionsgleichung

Reaktionsgleichung von HRID 18532
[C:1]1([NH2:8])[C:2]([NH2:7])=[CH:3][CH:4]=[CH:5][CH:6]=1.CO[C:11](=N)[C:12]([Cl:15])([Cl:14])[Cl:13].C1(C)C=CC=CC=1>C(O)(=O)C>[Cl:13][C:12]([Cl:15])([Cl:14])[C:11]1[NH:8][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=2[N:7]=1

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 7243O-PhenylenediamineHCID 100479Methyl 2,2,2-trichloroacetimidate

Produkt 1

HCID 77133Benzimidazole, 2-trichloromethyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 10 g Benzene-1,2-diamine in 250 mL acetic acid, 22.8 g 2,2,2-Trichloro-acetimidic acid methyl ester were added drop wise at RT. After 2 h 500 mL toluene were added and the solvents were removed under reduced pressure. The residue was codestilled additional two times with toluene. After drying under reduced pressure the product was pure enough for the next reaction step.

Aufarbeitung

  1. customthe solvents were removed under reduced pressure
  2. customAfter drying under reduced pressure the product
  3. customwas pure enough for the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-0afa7b3ef23347f6a27ba72298be89b9
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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