Water → 2-(2-Methoxyethoxy)-6-nitroaniline

HRID 18541

Reaktionsgleichung

Reaktionsgleichung von HRID 18541
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:11].Br[CH2:13][CH2:14][O:15][CH3:16].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[CH3:16][O:15][CH2:14][CH2:13][O:11][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[NH2:1]

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 41154952-Amino-3-Nitrophenol

Produkt 1

HCID 593496042-(2-Methoxyethoxy)-6-nitroaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 5 g 2-Amino-3-nitro-phenol, 4.5 g 1-Bromo-2-methoxy-ethane, 4.4 g K2CO3 in 50 mL DMF were heated to 60° C. for 16 h. Then 50 mL of water were added and the mixture was extracted with ethyl acetate (3×100 ml). The combined organic layers were dried over MgSO4, and the solvents were removed under reduced pressure. The remaining product was pure enough for the next reaction step. Yield: 5.8 g.

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate (3×100 ml)
  2. dry with materialThe combined organic layers were dried over MgSO4
  3. customthe solvents were removed under reduced pressure
  4. customThe remaining product was pure enough for the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-e4212dad419940b0b09a993a75280f66
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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