Hydrazine hydrate (1:1) → Tert-butyl(1-(hydrazinecarbonyl)cyclopropyl)methylcarbamate

HRID 1855186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1855186
C1N=CN(C(N2C=NC=C2)=O)C=1.[C:13]([O:17][C:18]([NH:20][CH2:21][C:22]1([C:25]([OH:27])=O)[CH2:24][CH2:23]1)=[O:19])([CH3:16])([CH3:15])[CH3:14].[NH2:28][NH2:29].O>C1COCC1>[C:13]([O:17][C:18](=[O:19])[NH:20][CH2:21][C:22]1([C:25]([NH:28][NH2:29])=[O:27])[CH2:24][CH2:23]1)([CH3:16])([CH3:15])[CH3:14]

Komponenten

5

Edukt 3

HCID 24654Hydrazine hydrate (1:1)HCID 682631,1'-CarbonyldiimidazoleHCID 51340346Boc-amcp-OH

Produkt 1

HCID 89834475Tert-butyl(1-(hydrazinecarbonyl)cyclopropyl)methylcarbamateAusbeute 84,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

CDI (12.5 g, 0.077 mol) was added to a 0° C. solution of 1-((tert-butoxycarbonylamino)methyl)cyclopropanecarboxylic acid (15.0 g, 0.07 mol) in THF (250 mL). The mixture was allowed to warm to rt, and stirred at rt. for 2 hrs, and then NH2NH2.H2O (10.5 g, 0.21 mol) was added rapidly. The mixture was stirred for another 1 hr. The reaction mixture was concentrated, and then CH2Cl2 (500 mL) was added. The combined organic layer was washed with H2O (100 mL), dried over Na2SO4, and concentrated to afford tert-butyl(1-(hydrazinecarbonyl)cyclopropyl)methylcarbamate (13.5 g, 84%). ESI-MS (EI+, m/z): 230.2 [M+H]+.

Aufarbeitung

  1. stirringThe mixture was stirred for another 1 hr
  2. concentrationThe reaction mixture was concentrated
  3. additionCH2Cl2 (500 mL) was added
  4. washThe combined organic layer was washed with H2O (100 mL)
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a22c7f7bc3d74c17b7861722f9cf1158
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962843B2

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