tert-Butoxy bis(dimethylamino)methane → Ethyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylate

HRID 1855363

Reaktionsgleichung

Reaktionsgleichung von HRID 1855363
[O:1]=[C:2]([C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].C(O[CH:24](N(C)C)[N:25]([CH3:27])[CH3:26])(C)(C)C>>[CH3:24][N:25]([CH3:27])[CH:26]=[C:3]([C:2](=[O:1])[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:11][CH:10]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Komponenten

3

Edukt 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 2760281Ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate

Produkt 1

HCID 54156258Ethyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylate

Versuchsvorschrift

Ethyl 3-oxo-3-(4-trifluoromethyl-phenyl)-propionate (130 mg, 0.5 mmol) was reacted with tert.-butoxy-bis-(dimethylamino)-methane using in analogous manner the procedure described in example 28a) to give crude title compound (151 mg) as a red oil which was used directly in the next step.

Quellen und Nachweise

ORD-Eintrag
ord-f9708dd493ec47e3ac8f58fca8d358b2
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962834B2

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