Trifluoroacetic acid → HCID 178510940, Verbindung

HRID 1855661

Reaktionsgleichung

Reaktionsgleichung von HRID 1855661
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C([N:27]1[CH:31]=[C:30]([CH2:32][CH2:33][CH2:34][NH2:35])[N:29]=[CH:28]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)Cl.CCOC(C)=O.O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:27]1[CH:31]=[C:30]([CH2:32][CH2:33][CH2:34][NH2:35])[N:29]=[CH:28]1

Komponenten

6

Edukt 2

HCID 6422Trifluoroacetic acidHCID 153458253-(1-trityl-1H-imidazol-4-yl)propan-1-amine

Produkt 1

HCID 178510940HCID 178510940, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2 ml of trifluoroacetic acid are added to 195 mg (0.53 mmol) of 3-(1-trityl-1H-imidazol-4-yl) propylamine dissolved in 8 ml of DCM and then immersed in an ice bath. After warming to room temperature, the reaction medium is stirred for 2 hours and the solvents are then evaporated off. The solid obtained is taken up in EtOAc and water. The aqueous phase is then concentrated and 110 mg of a white powder are obtained and used in the next step without further purification.

Aufarbeitung

  1. customimmersed in an ice bath
  2. customthe solvents are then evaporated off
  3. customThe solid obtained
  4. concentrationThe aqueous phase is then concentrated

Quellen und Nachweise

ORD-Eintrag
ord-e5f2840a2cd44d209ed34f98dc3dd253
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962846B2

Verknüpfte Notizen

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