Hydrochloric Acid → 1-Methylpiperidine-2-carboxylic acid

HRID 1856626

Reaktionsgleichung

Reaktionsgleichung von HRID 1856626
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[CH3:12])=[O:5])C.[OH-].[Na+].Cl>CO.O>[CH3:12][N:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[C:4]([OH:5])=[O:3]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 566742Ethyl 1-methylpiperidine-2-carboxylate

Produkt 1

HCID 4159391-Methylpiperidine-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

Aufarbeitung

  1. customevaporated to dryness
  2. customevaporated four times with toluene

Quellen und Nachweise

ORD-Eintrag
ord-c8aa0ec772a14ba6bae873e47ddda8c5
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06143721

Verknüpfte Notizen

Wird geladen…