Butyl isocyanate → HCID 22667145, Verbindung

HRID 1857224Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1857224
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1.[CH2:23]([N:27]=[C:28]=[O:29])[CH2:24][CH2:25][CH3:26]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:28]([NH:27][CH2:23][CH2:24][CH2:25][CH3:26])=[O:29])=[CH:18][CH:17]=1

Komponenten

4

Edukt 2

HCID 8110Butyl isocyanateHCID 116163634-(6,7-Dimethoxyquinazolin-4-yloxy)aniline

Produkt 1

HCID 22667145HCID 22667145, VerbindungAusbeute 56 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

6,7-Dimethoxy-4-(4-aminophenoxy)quinazoline (100 mg) was dissolved in toluene (10 ml) with heat, n-butyl isocyanate (0.29 ml) was added, and the admixture was refluxed with heat for 40 minutes. After removing the solvent by distillation, the resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (5/1) to obtain 75 mg of the title compound (yield: 56%).

Aufarbeitung

  1. temperaturewith heat
  2. temperaturethe admixture was refluxed
  3. temperaturewith heat for 40 minutes
  4. customAfter removing the solvent
  5. distillationby distillation
  6. customthe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (5/1)

Quellen und Nachweise

ORD-Eintrag
ord-1fe79b7dff5246f9839e32ba7e24cc06
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06143764

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