Sodium Thiosulfate → N-(2-Amino-4-chlorophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

N-(4-Chloro-2-nitrophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea (158 mg) was dissolved in chloroform/methanol/water (10 ml/70 ml/5 ml), sodium thiosulfate (1.01 g) was added, and the admixture was stirred at 60° C. for 37 minutes. The reaction mixture was extracted 2 times with chloroform, and the organic layer was then washed with brine and dried with anhydrous sodium sulfate. The solvent was removed by reduced-pressure distillation, and the resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 33 mg of the title compound (yield: 22%).

1. extractionThe reaction mixture was extracted 2 times with chloroform
2. washthe organic layer was then washed with brine
3. dry with materialdried with anhydrous sodium sulfate
4. customThe solvent was removed by reduced-pressure distillation
5. customthe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1)

ORD-Eintrag

ord-3f4b7d8bf2504339933f25a6c41f5582

Quelldatensatz

uspto-grants-2000_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06143764