8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	8-(3,4-Difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol	HCID 22122104	—
Lösungsmittel	Acetone	HCID 180	—
Lösungsmittel	Hydrochloric Acid	HCID 313	—
Produkt	4-(3,4-Difluorophenyl)-4-hydroxycyclohexanone	HCID 22122090	48%

Reaktionsschritte

A solution of 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol (3 mmole) in acetone (100 ml) and concentrated HCl (1 ml) was reacted as described in example 25 to give the product (48%, mp: 84-85° C.). Calc'd for C12H12F2O2 : C, 63.72%; H, 5.35%. Found: C, 62.72%; H, 5.24%.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06153611
Quelldatensatz	uspto-grants-2000_11
ORD ID	ord-5900ea93f44047e7ac464e409abfa657
Quellennotiz	uspto-grants-2000_11