Acetone → 3-{Benzyl-[2-(2-bromophenyl)-2-oxoethyl]amino}propanenitrile

HRID 1859048Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859048
[Br:1][CH:2](Br)[C:3]([C:5]1C=CC=[CH:7][CH:6]=1)=O.[CH2:12]([NH:19][CH2:20][CH2:21][C:22]#[N:23])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(C(C)C)CC)(C)C.[CH3:33][C:34]([CH3:36])=[O:35]>>[CH2:12]([N:19]([CH2:33][C:34]([C:36]1[CH:7]=[CH:6][CH:5]=[CH:3][C:2]=1[Br:1])=[O:35])[CH2:20][CH2:21][C:22]#[N:23])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Komponenten

5

Edukt 4

HCID 180Acetone2×HCID 697193-(Benzylamino)propionitrileHCID 81531DiisopropylethylamineHCID 5694832,2-Dibromo-1-phenylethanone

Produkt 1

HCID 221232153-{Benzyl-[2-(2-bromophenyl)-2-oxoethyl]amino}propanenitrile

Versuchsvorschrift

A solution of 97.5 g of 2-bromo-α-bromoacetophenone in 200 ml of acetone is poured dropwise, at ambient temperature, into a solution of 61.7 g de N-benzyl-2-cyanoethylamine and 67 ml of diisopropylethylamine in 200 ml of acetone. After stirring for 12 hours, the reaction mixture is evaporated, taken up in ether, washed twice with 500 ml of water each time and dried. After evaporating under reduced pressure, 131.9 g of expected product are obtained.

Aufarbeitung

  1. customthe reaction mixture is evaporated
  2. washwashed twice with 500 ml of water each time
  3. customdried
  4. customAfter evaporating under reduced pressure, 131.9 g of expected product
  5. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-4867d9ab7c3c41749cd527be64aa2e65
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06153640

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