Phosphonic acid → N-methyl-N-(phosphonomethyl)glycine

HRID 1859241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859241
[C:1]([N:4]([CH2:6][C:7]([OH:9])=[O:8])[CH3:5])(=O)C.C=O.[OH:12][PH:13]([OH:15])=[O:14].P(Cl)(Cl)Cl>>[P:13]([CH2:1][N:4]([CH3:5])[CH2:6][C:7]([OH:9])=[O:8])([OH:15])([OH:14])=[O:12]

Komponenten

5

Edukt 4

HCID 407Phosphonic acid2×HCID 712FormaldehydeHCID 24387Phosphorus trichlorideHCID 10975514N-Acetyl-N-methylglycine

Produkt 1

HCID 541499N-methyl-N-(phosphonomethyl)glycine

Versuchsvorschrift

As depicted, the carboxymethylation step of Reaction Scheme 12 is the same as the carboxymethylation step of Reaction Schemes 10 and 11. In Reaction Scheme 12, however, N-acetylsarcosine XX is reacted with formaldehyde and H3PO3, PCl3 or other H3PO3 source to produce N-(phosphonomethyl)-N-methyl-glycine XXI which is oxidized in the presence of a platinum catalyst and oxygen to Glyphosate I and acetic acid. The acetic acid is then reacted with methylamine to yield the N-methylacetamide starting material.

Aufarbeitung

  1. customthe carboxymethylation step of Reaction Scheme 12
  2. customsame as the carboxymethylation step of Reaction Schemes 10 and 11
  3. customIn Reaction Scheme 12

Quellen und Nachweise

ORD-Eintrag
ord-c4a8534e865f4f87b8080904090f1e79
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06153753

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