Ethanol → 1-(4,4,5,5,5-Pentafluoropentyl)piperazine

HRID 1859347Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859347
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(O)C.[F:10][C:11]([F:31])([C:27]([F:30])([F:29])[F:28])[CH2:12][CH2:13][CH2:14]OC1C=CC=C(C)C=1S([O-])(=O)=O>O>[F:10][C:11]([F:31])([C:27]([F:30])([F:29])[F:28])[CH2:12][CH2:13][CH2:14][N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 4837PiperazineHCID 867560744,4,5,5,5-Pentafluoropentyloxytoluenesulfonate

Produkt 1

HCID 221236141-(4,4,5,5,5-Pentafluoropentyl)piperazineAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Piperazine (777 mg, 9.0 mmol) was added to ethanol solution (10 ml) of 4,4,5,5,5-pentafluoropentyloxytoluenesulfonate (600 mg, 1.81 mmol) and then heated under refluxing for 40 hours. After adding water, the reaction solution was extracted with ethyl acetate. The solvent was distilled off under reduced pressure from the extract to obtain 315 mg (yield: 100%) of the title compound.

Aufarbeitung

  1. temperatureheated
  2. temperatureunder refluxing for 40 hours
  3. extractionthe reaction solution was extracted with ethyl acetate
  4. distillationThe solvent was distilled off under reduced pressure from the
  5. extractionextract

Quellen und Nachweise

ORD-Eintrag
ord-f963d98051544e3db366144d0bfe444d
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06153768

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