5-Chloro-4-methoxy-2-nitroaniline → HCID 22573123, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[C:3]([O:12][CH3:13])=[CH:4][C:5]([N+:9]([O-])=O)=[C:6]([NH2:8])[CH:7]=1>[Pd].CCOC(C)=O>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([NH2:9])=[CH:4][C:3]=1[O:12][CH3:13]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of EtOAc (25 mL) and 5-chloro-4-methoxy-2-nitro-phenylamine (1.6 g , 7.9 mmol) under argon is added 5% Pd/C (0.5 g). The reaction mixture is hydrogenated at 50 psi for 1 hour. The mixture is filtered under N2 through Celite into a solution of 1 N HCl/Et2O in EtOAc, and the pad is washed with additional EtOAc. The resulting precipitate is filtered off to provide a white solid.
Aufarbeitung
- filtrationThe mixture is filtered under N2 through Celite into a solution of 1 N HCl/Et2O in EtOAc
- washthe pad is washed with additional EtOAc
- filtrationThe resulting precipitate is filtered off
- customto provide a white solid
Quellen und Nachweise
- ORD-Eintrag
- ord-a1c7fe5339ef4161b4b32f965f735617
- Quelldatensatz
- uspto-grants-2003_03
- Patentnummer
- US06528526B1
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