Methyl acetoacetate → 5-Hydroxy-6-methyl-5-[2-(4-methyl-thiazol-5-yl)ethyl]-3-oxo-heptanoic acid methyl ester
Reaktionsgleichung
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[H-].[Na+].[Li]CCCC.[CH3:16][CH:17]([CH3:28])[C:18](=[O:27])[CH2:19][CH2:20][C:21]1[S:25][CH:24]=[N:23][C:22]=1[CH3:26]>>[CH3:8][O:7][C:1](=[O:6])[CH2:2][C:3](=[O:4])[CH2:5][C:18]([OH:27])([CH2:19][CH2:20][C:21]1[S:25][CH:24]=[N:23][C:22]=1[CH3:26])[CH:17]([CH3:16])[CH3:28]Komponenten
5
Versuchsvorschrift
The title compound was prepared as described in General Method 6 from 1.00 g (8.61 mmol) of methyl acetoacetate, 0.38 g (9.50 mmol) of sodium hydride, 4.5 mL of 2.1 M nBuLi (9.45 mmol), and 1.53 g (7.75 mmol) of 4-methyl-1-(4-methyl-thiazol-5-yl)-pentan-3-one (prepared in Example C-2.) The crude compound was used without purification in the next step.