Potassium Carbonate → 5-Isopropyl-2-nitroaniline

HRID 1859555Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859555
FC(F)(F)C([NH:5][C:6]1[CH:11]=[C:10]([CH:12]([CH3:14])[CH3:13])[CH:9]=[CH:8][C:7]=1[N+:15]([O-:17])=[O:16])=O.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH:12]([C:10]1[CH:9]=[CH:8][C:7]([N+:15]([O-:17])=[O:16])=[C:6]([NH2:5])[CH:11]=1)([CH3:14])[CH3:13]

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 225730622,2,2-Trifluoro-N-(5-isopropyl-2-nitro-phenyl)-acetamide

Produkt 1

HCID 225728525-Isopropyl-2-nitroaniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

2,2,2-Trifluoro-N-(5-isopropyl-2-nitro-phenyl)-acetamide (prepared in Example OO-1; 9.4 g, 34 mmol) was dissolved in MeOH (30 mL) and treated with 7% aqueous potassium carbonate solution. The reaction mixture was stirred overnight at room temperature. The reaction was diluted with water (30 mL) and extracted with EtOAc (3×50 mL). The organic layer was washed with saturated NaHCO3 solution and brine, dried (MgSO4), and concentrated. The crude product was used further without any purification. MS(APCI): 181 (M+H).

Aufarbeitung

  1. extractionextracted with EtOAc (3×50 mL)
  2. washThe organic layer was washed with saturated NaHCO3 solution and brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated
  5. customThe crude product was used further without any purification

Quellen und Nachweise

ORD-Eintrag
ord-c5e5da97a19e44b8b2db18b23ded8d49
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06528510B1

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