Sodium Hydroxide → 2-(5-(Trifluoromethyl)pyridin-2-yl)benzoic acid

HRID 1860052

Reaktionsgleichung

Reaktionsgleichung von HRID 1860052
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([O:13]C)=[O:12])=[CH:7][CH:8]=1.[OH-].[Na+]>>[F:20][C:2]([F:1])([F:19])[C:3]1[CH:4]=[N:5][C:6]([C:9]2[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([OH:13])=[O:12])=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 18625897Methyl 3-trifluoromethylpyridine-6-ylbenzoate

Produkt 1

HCID 227369092-(5-(Trifluoromethyl)pyridin-2-yl)benzoic acidAusbeute 72,7 %

Versuchsvorschrift

In a similar manner to that described in Example 2, a reaction was carried out using methyl 3-trifluoromethylpyridine-6-ylbenzoate (791 mg) and aqueous sodium hydroxide solution (1N, 5.60 ml) and the reaction mixture was treated to afford the title compound (546 mg) which includes some impurity and was used in example 106 without further purification.

Aufarbeitung

  1. additionthe reaction mixture was treated

Quellen und Nachweise

ORD-Eintrag
ord-c54feab767b34f7c8e3d3a9cfdd867f1
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06528525B1

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