Methanol → HCID 18619223, Verbindung

Reaktionsgleichung

C([O:4][C:5]1[C:6]([O:11][C:12]2[CH:17]=[C:16]([N:18]3[C:23](=[O:24])[CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[N:20]([CH3:29])[C:19]3=[O:30])[C:15]([F:31])=[CH:14][C:13]=2[Cl:32])=[N:7][CH:8]=[CH:9][CH:10]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>C(O)(=O)C>[Cl:32][C:13]1[CH:14]=[C:15]([F:31])[C:16]([N:18]2[C:23](=[O:24])[CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[N:20]([CH3:29])[C:19]2=[O:30])=[CH:17][C:12]=1[O:11][C:6]1[C:5]([OH:4])=[CH:10][CH:9]=[CH:8][N:7]=1

Komponenten

Versuchsvorschrift

A mixture of 100 mg of 3-acetoxy-2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}pyridine, 15 mg of potassium carbonate and 1 ml of methanol was stirred for 3 hours at room temperature. The reaction solution was poured into ice water, then, to this was poured acetic acid. The precipitated crystals were collected by filtration to obtain 65 mg of 2-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-3-hydroxypyridine