Potassium tert-butoxide → 2-methyl-2H-pyran-3,5(4H,6H)-dione

HRID 1862447Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1862447
CC(C)([O-])C.[K+].[CH3:7][CH:8]([O:12][CH2:13][C:14]([O:16]C)=O)[C:9](=[O:11])[CH3:10]>C(O)(C)(C)C.CCOCC>[CH3:7][CH:8]1[C:9](=[O:11])[CH2:10][C:14](=[O:16])[CH2:13][O:12]1

Komponenten

5

Edukt 2

HCID 23665647Potassium tert-butoxideHCID 71360827Methyl (1-methyl-2-oxopropoxy)acetate

Produkt 1

HCID 234974742-methyl-2H-pyran-3,5(4H,6H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

Potassium tert-butoxide in tert-butanol (1 M, 203 mL) and the product from Example 44B (15.5 g, 97 mmol) in ether (55 mL) were processed as described in Example 43C. The residue was purified on silica gel eluting with ethyl acetate:formic acid:water:hexane (200:1:1:200) provided the title compound. 1H NMR (CDCl3) δ 1.48 (d, 3H), 3.43 (d, 1H), 3.92 (d, 1H), 3.97 (q, 1H), 4.04 (d, 1H), 4.44 (d, 1H).

Aufarbeitung

  1. customThe residue was purified on silica gel eluting with ethyl acetate:formic acid:water:hexane (200:1:1:200)

Quellen und Nachweise

ORD-Eintrag
ord-cc7df6c706fb4b2ba3e108b6efc09c26
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06538004B2

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