Acetic Acid → HCID 69058281, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[O:19][CH2:20][C@@H:21]([NH:23][CH3:24])[CH3:22])[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:4][C:3]=1[OH:25].[C:26]([OH:29])(=O)[CH3:27]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][C:17]=3[O:19][CH2:20][C@@H:21]([N:23]([CH3:24])[C:26](=[O:29])[CH3:27])[CH3:22])[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:4][C:3]=1[OH:25]Komponenten
3
Versuchsvorschrift
The procedure described in Example 3 (preparation of starting materials) was repeated using acetic acid and 2-chloro-4-[(5-{[(2S)-2-(methylamino)propyl]oxy}quinazolin-4-yl)amino]phenol (obtained as described in Example 56, preparation of starting materials) to give N-[(1S)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)-1-methylethyl]-N-methylacetamide in 27% yield; Mass spectrum MH+ 401.3.
Aufarbeitung
- customThe procedure described in Example 3 (preparation of starting materials)