Acetic Acid → HCID 69020176, Verbindung

HRID 1865127

Reaktionsgleichung

Reaktionsgleichung von HRID 1865127
[CH3:1][S:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1.[C:16]1([CH3:28])[CH:21]=[CH:20][C:19]([S:22]([CH2:25][C:26]#[N:27])(=[O:24])=[O:23])=[CH:18][CH:17]=1.N1CCCCC1.C(O)(=O)C>C1(C)C=CC=CC=1>[CH3:28][C:16]1[CH:17]=[CH:18][C:19]([S:22]([C:25](=[CH:12][C:11]2[CH:14]=[CH:15][C:8]([C:4]3[S:5][CH:6]=[CH:7][C:3]=3[S:2][CH3:1])=[CH:9][CH:10]=2)[C:26]#[N:27])(=[O:24])=[O:23])=[CH:20][CH:21]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 79776TosylacetonitrileHCID 57975359HCID 57975359, Verbindung

Produkt 1

HCID 69020176HCID 69020176, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a stirring solution of 4-(3-methylthio-2-thienyl)benzaldehyde (1.0 mmol, prepared directly above) and p-toluenesulphonylacetonitrile (1.0 mmol) in toluene, add piperidine (0.05 mmol) and acetic acid (0.3 mmol). Heat the reaction mixture to reflux for 2 hours while using a Dean-Stark trap, remove the heat and concentrate the reaction in vacuo. The crude material can be carried on to the next step without further purification.

Aufarbeitung

  1. temperatureHeat the reaction mixture
  2. temperatureto reflux for 2 hours
  3. customremove the
  4. temperatureheat
  5. concentrationconcentrate
  6. customthe reaction in vacuo
  7. customThe crude material can be carried on to the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-e678d31c3812410c82607739188924b7
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07625932B2

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