Dichloroacetic Acid → HCID 54724182, Verbindung

HRID 1867023Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1867023
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]1=[O:13].[I:17]N1C(=O)CCC1=O.ClC(Cl)C(O)=O>C(#N)C>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([I:17])[C:7]1=[O:13]

Komponenten

5

Edukt 3

HCID 6597Dichloroacetic AcidHCID 120273N-IodosuccinimideHCID 54724162HCID 54724162, Verbindung

Produkt 1

HCID 54724182HCID 54724182, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a mixture of 1-(3-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (1.1 g, 5 mmol) in acetonitrile (15 mL) was added N-iodosuccinimide (1.1 g, 5.5 mmol) along with a ca. amount of dichloroacetic acid (0.1 mL). The reaction mixture stirred at room temperature for 1 hour under nitrogen. The mixture was chilled in an ice bath and filtered cold with fresh MeCl2. The beige solid was dried to afford the desired iodinated intermediate (1.21 g, 69%). ES-LRMS m/z 346.

Aufarbeitung

  1. temperatureThe mixture was chilled in an ice bath
  2. filtrationfiltered cold with fresh MeCl2
  3. customThe beige solid was dried
  4. customto afford the

Quellen und Nachweise

ORD-Eintrag
ord-dce047879a5148b7bccca72715b1a0db
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07629363B2

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