HCID 68434037, Verbindung → Hexahydro-7-methyl-5H-1,4-diazepin-5-one

HRID 1867389Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1867389
C(OC([N:11]1[CH:17]([CH3:18])[CH2:16][C:15](=[O:19])[NH:14][CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:18][CH:17]1[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:19])[CH2:16]1

Komponenten

4

Edukt 1

HCID 68434037HCID 68434037, Verbindung

Produkt 1

HCID 45117250Hexahydro-7-methyl-5H-1,4-diazepin-5-oneAusbeute 82,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 7-methyl-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester (201 mg, 0.77 mmol) and palladium (10% on activated charcoal, 80 mg) in ethanol (2 ml) was stirred at room temperature under a hydrogen atmosphere (3 bar). After 20 h, the catalyst was removed by filtration and the filtrate evaporated to afford the title compound (81 mg, 82%). White solid,

Aufarbeitung

  1. customthe catalyst was removed by filtration
  2. customthe filtrate evaporated

Quellen und Nachweise

ORD-Eintrag
ord-9ad9ecf658c14e3e84ccf9d299552800
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07632829B2

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