Hydrogen Bromide → HCID 136388604, Verbindung
Reaktionsgleichung
[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][CH2:17][CH2:18][F:19])=[CH:12][C:11]=3[O:20]C)[CH:8]=[CH:9][C:2]=12.Br>C(O)(=O)C>[N:1]1[O:5][N:4]=[C:3]2[CH:6]=[C:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][CH2:17][CH2:18][F:19])=[CH:12][C:11]=3[OH:20])[CH:8]=[CH:9][C:2]=12Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
10 mg (0.03 mmol) of (4-benzo[1,2,5]oxadiazol-5-yl-3-methoxy-phenyl)-(2-fluoro-ethyl)-amine are dissolved in 0.3 mL acetic acid and 0.3 mL hydrobromic acid (33% in acetic acid) and stirred at 80 QC for 72 h. Then the solvents are removed. The mixture of starting material and desired product can be separated by HPLC (20 to 100% CH3CN/H2O (6′), 100% CH3CN (1.5°), 100 to 20% CH3CN/H2O (0.5°): product elutes after 4.5°). MS(ES+): 274 (M+1).