Chloral Hydrate → HCID 86607005, Verbindung

Reaktionsgleichung

[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][NH:9][CH2:8][CH2:7]2.Cl[C:13](Cl)(Cl)[CH:14]([OH:16])O.Cl.[NH2:20][OH:21]>>[CH2:10]1[C:11]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[NH:1][C:14](=[O:16])[CH:13]=[N:20][OH:21])[CH2:7][CH2:8][NH:9]1

Komponenten

Edukt 3

HCID 2707Chloral Hydrate

HCID 443297Hydroxyamine hydrochloride

HCID 205232091,2,3,4-Tetrahydroisoquinolin-8-amine2×

Produkt 1

HCID 86607005HCID 86607005, Verbindung

Versuchsvorschrift

Reacting an 8-amino-1,2,3,4-tetrahydro-isoquinoline (Compound 9) derivative with chloral hydrate and hydroxylamine hydrochloride to give an N-(1,2,3,4-tetrahydro-isoquinolin-8-yl)-2-hydroxyimino-acetamide (Compound 10) derivative (Step 9);

Quellen und Nachweise

ORD-Eintrag: ord-9aafc461dbd44cf48c86204b47879f9b
Quelldatensatz: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07632948B2

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