Methanol → 5-Methyl-1H-indazol-4-amine

HRID 1869404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1869404
Cl[C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[CH3:12]O>[Pd]>[CH3:12][C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 887MethanolHCID 179892615-Chloro-1H-indazol-4-amine

Produkt 1

HCID 193544325-Methyl-1H-indazol-4-amineAusbeute 6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

Analogously to the production of 5-chloro-1H-indazol-4-ylamine, the regioisomeric mixture of the previous reaction (1.0 g, 5.64 mmol)) is reacted with 100 mg of palladium on carbon in methanol under hydrogen atmosphere for 16 hours at room temperature. After purification on silica gel with hexane/ethyl acetate (33% hexane, then 100% ethyl acetate), 53 mg (6% of theory) of 5-methyl-1H-indazol-4-ylamine is obtained.

Aufarbeitung

  1. customAfter purification on silica gel with hexane/ethyl acetate (33% hexane

Quellen und Nachweise

ORD-Eintrag
ord-f0cce4393a6640e1a4afcd8e29369f38
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07638515B2

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