Oxaprozin → Butanedioic acid;bis(2-hydroxy-1,2-diphenylethanone)

HRID 1870491

Reaktionsgleichung

C1(C2N=[C:9]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])[O:10]C=2C2C=CC=CC=2)C=CC=CC=1.[C:23]1([C:29]([CH:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[OH:32])=[O:30])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C1(=O)OC(=O)CC1>>[C:20]([OH:22])(=[O:21])[CH2:19][CH2:18][C:9]([OH:30])=[O:10].[C:23]1([C:29]([CH:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[OH:32])=[O:30])[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1.[C:23]1([C:29]([CH:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[OH:32])=[O:30])[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Komponenten

Edukt 3

HCID 4614Oxaprozin

HCID 7922Succinic anhydride

HCID 8400Benzoin

Produkt 1

HCID 131711721Butanedioic acid;bis(2-hydroxy-1,2-diphenylethanone)

Versuchsvorschrift

A process for the preparation of 4,5-diphenyloxazole-2-propanoic acid of formula I ##STR2## by esterification of benzoin with succinic anhydride to give benzoin hemisuccinate, and cyclization to (I) by direct addition of ammonium acetate or urea to the mixture containing the hemisuccinate,

Quellen und Nachweise

ORD-Eintrag: ord-cf112545ea7f4486bef9bbf657337f54
Quelldatensatz: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06096896

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