Water → HCID 18689385, Verbindung

HRID 1871843Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871843
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[C:2]1=[C:11]1[C:15]([CH3:17])([CH3:16])[O:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([O:24]C)[CH:19]=3)=[N:12]1)[CH2:8]2.B(I)(I)I.O>C(Cl)Cl>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[C:2]1=[C:11]1[C:15]([CH3:17])([CH3:16])[O:14][C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[CH:19]=3)=[N:12]1)[CH2:8]2

Komponenten

5

Edukt 3

HCID 962Water2×HCID 83546Borane, triiodo-HCID 18689382HCID 18689382, Verbindung

Produkt 1

HCID 18689385HCID 18689385, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 7 mmol 4-adamantylidene-2-(3'-methoxyphenyl)-5,5-dimethyl-oxazoline in 20 ml absolute methylene chloride is added dropwise to a solution of 14 mmol boron triiodide while stirring at -25° C. with the exclusion of air and water. The mixture is heated to room temperature within one hour and stirred for a further 4 h. After admixing with 50 ml water the organic phase is separated and dried over sodium sulfate. The solvent is removed by distillation. The oily residue is separated by column chromatography (silica gel: ethyl acetate/petroleum ether 1:3).

Aufarbeitung

  1. customis separated
  2. dry with materialdried over sodium sulfate
  3. customThe solvent is removed by distillation
  4. customThe oily residue is separated by column chromatography (silica gel: ethyl acetate/petroleum ether 1:3)

Quellen und Nachweise

ORD-Eintrag
ord-12c853bd71b7413486a92e4a70faa90d
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06107036

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