Water → 1-(Bromomethyl)-3-ethylbenzene

HRID 1871982

Reaktionsgleichung

Reaktionsgleichung von HRID 1871982
P(Br)(Br)[Br:2].[CH2:5]([C:7]1[CH:8]=[C:9]([CH2:13]O)[CH:10]=[CH:11][CH:12]=1)[CH3:6].O>C1C=CC=CC=1>[Br:2][CH2:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([CH2:5][CH3:6])[CH:8]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 104659(3-Ethylphenyl)methanol

Produkt 1

HCID 220036561-(Bromomethyl)-3-ethylbenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Phosphorous tribromide (5.3 ml) was added to a solution of the product from step (i) (7.6 g) in benzene (150 ml) at 0° C. After 3 hours, water (40 ml) was added and the mixture warmed to room temperature and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 2% ethyl acetate in isohexane. Yield 8.0 g.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated
  4. customPurified by chromatography
  5. washeluting with 2% ethyl acetate in isohexane

Quellen und Nachweise

ORD-Eintrag
ord-b501f9e1eb8544469e9e0de14223e35f
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06107297

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