Methyl iodide → HCID 178503573, Verbindung

HRID 1871998Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871998
IC.[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19](=[S:25])[NH:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1.[C:28](=O)(O)[O-].[Na+]>C(O)C.O>[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19]([S:25][CH3:28])=[N:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1

Komponenten

6

Edukt 3

HCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 18689719HCID 18689719, Verbindung

Produkt 1

HCID 178503573HCID 178503573, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Iodomethane (0.2 ml) was added to a stirred suspension of the product from step (i) (0.65 g) and sodium bicarbonate (0.4 g) in ethanol (15 ml) and water (4 ml). After stirring for 30 min, the reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water, dried (MgSO4) and evaporated under reduced pressure. The residue was triturated with ether and filtered. Yield 0.49 g.

Aufarbeitung

  1. washthe reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with ether
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-19a02dd9780f4f77a7f4c8e0c691c1ba
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06107297

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