2-(4-Ethoxy-2,3-difluorophenyl)-5-but-1-enylselenophene → 2-(4-Ethoxy-2,3-difluorophenyl)-5-butylselenophene

HRID 1873402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1873402
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[Se:11][C:12]([CH:15]=[CH:16][CH2:17][CH3:18])=[CH:13][CH:14]=2)=[C:6]([F:19])[C:5]=1[F:20])[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[Se:11][C:12]([CH2:15][CH2:16][CH2:17][CH3:18])=[CH:13][CH:14]=2)=[C:6]([F:19])[C:5]=1[F:20])[CH3:2]

Komponenten

4

Edukt 1

HCID 722902482-(4-Ethoxy-2,3-difluorophenyl)-5-but-1-enylselenophene

Produkt 1

HCID 594563002-(4-Ethoxy-2,3-difluorophenyl)-5-butylselenophene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2.30 g (6.22 mmol) of 2-(4-ethoxy-2,3-difluorophenyl)-5-but-1-enylselenophene are hydrogenated in 70 ml of ethyl acetate, in the presence of Pd/C (5% of Pd) at atmospheric pressure and RT. The reaction soln. is filtered and concentrated to dryness, and the crude product is purified by recrystallisation from n-heptane. 2-(4-Ethoxy-2,3-difluorophenyl)-5-butylselenophene is obtained as a colourless solid (m.p. 47° C.).

Aufarbeitung

  1. filtrationis filtered
  2. concentrationconcentrated to dryness
  3. customthe crude product is purified by recrystallisation from n-heptane

Quellen und Nachweise

ORD-Eintrag
ord-256a354663ba448cb85aae320f3dcfb0
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08304036B2

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