2-Nitro-5-(3-nitrophenoxy)pyridine → 5-(3-Aminophenoxy)pyridin-2-amine

HRID 1874321

Reaktionsgleichung

Reaktionsgleichung von HRID 1874321
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[CH:12]=2)=[CH:6][N:5]=1)([O-])=O>CO.[C].[Pd]>[NH2:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[O:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[N:5][CH:6]=1

Komponenten

4

Edukt 1

HCID 577491152-Nitro-5-(3-nitrophenoxy)pyridine

Produkt 1

HCID 577491665-(3-Aminophenoxy)pyridin-2-amineAusbeute 96,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-nitro-5-(3-nitrophenoxy)pyridine (1.33 g, 5.07 mmol) in methanol (10 mL) was added palladium carbon (50% water-containing product, 100 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 12 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure and dried to give the title compound (980 mg, 96%) as a yellow oil.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a81113a96572486e82148948405ef910
Quelldatensatz
uspto-grants-2012_11
Patentnummer
US08304557B2

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